Tuesday, April 17, 2007

Protein Secondary Structure Prediction with Bidirectional LSTM Networks

While trying to find out how bidirectional LSTM's work, we happened on this article about protein structure prediction. Fascinating though protein structures may be, we're more interested in the good description of the BLSTM algorithm.
Prediction of protein secondary structure is one of the classical problems in bioinformatics, which is still far from being satisfactorily solved. The Long Short-Term Memory(LSTM) algorithm is a very general and promising adaptive sequence processing device with a wide field of potential applications. In this paper, we proposed a Bidirectional LSTM(BLSTM) for PSS prediction and obtained encouraging results on the RS126 and CB396 sets.

Chapter III.A describes the inner workings of a bidirectional LSTM quite clearly.

- Jasper

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